The idea of the project is to develop a user friendly knowledgebase that contains all proteins that are cleaved by caspase enzymes. The proteins are graphically represented to facilitate the analysis and studying of caspases substrates. Each protein file contains rich information such as the cleaving caspase(s), the exact cleavage position, functional domains, biological implications of the cleavage process, and links for the pathway and interaction for each protein. The database offers easy to use searching tools that allow simple as well as advanced search. The database will be freely available via a web site through Palestine Polytechnic University’s server. The unique feature of this database is its ability to evolve through the contribution of browsers (biologists) from all around the world. The browsers can contribute to grow the database through adding more caspase substrates or editing already available data. The contributions of browsers were designed in a way to ensure high security data entry as well as to minimize effort needed by the administrators to follow-up and validate the contributions. In addition, our database is capable to automatically and regularly update all its content based on recent data that is available through various central databases such as Uniprot and PubMed.. Keywords; Caspases; Knowledgebase; Substrate.