Biotechnology that benefits Palestine. In particular veterinary virology and blood group genotyping
Rotavirus surveillance on Palestinian farms and serotype determination of infected ruminants suffering from scours.
Determination by PCR of ABO blood group using DNA extracted from samples of forensic interest.
International Refereed: (Average impact factor = 7.3)
Abu Ghazaleh.R, Kabir.J, Jia.H, Lobo.M, Zachary.I. (2001) Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 360:255-264. [Impact factor 4.371 Feb 2010]
Gliki.G, Abu Ghazaleh.R, Jezequel.S, Wheeler-Jones.C, Zachary.I. (2001) Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+. Biochem J 353:503-512. [Impact factor 4.371 Feb 2010]
Fry.E, Lea.S, Jackson.T, Newman.J, Ellard.F, Blakemore.W, Abu Ghazaleh.R, Samuel.W, King.A.M.Q, Stuart.D. (1999) The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. The EMBO Journal 18:543-554. [Impact factor 8.295 Feb 2010]
Wheeler-Jones.C, Abu Ghazaleh.R, Cospedal.R, Houliston.R, Martin.J. Zachary.I. (1997) vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Letters 420:28-32. [Impact factor 3.264 Feb 2010]
Curry.S, Fry.E, Blakemore.W, Abu Ghazaleh.R, Jackson.T, King.A, Lea.S, Newman.J, Stuart.D. (1997) Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilisation: the structure of empty capsids of foot-and-mouth disease virus. J Virology 71:9743-9752. [Impact factor 5.308 Feb 2010]
Jackson.T, Sharma.A, Abu Ghazaleh.R, Blakemore.W, Ellard.F, Simmons.D, Newman.J, Stuart.D, King.A.M.Q. (1997) Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha V beta 3 in vitro. J Virology 71:8357-8361. [Impact factor 5.308 Feb 2010]
Jackson.T, Ellard.F, Abu Ghazaleh.R, Brookes.S, Blakemore.W, Corteyn.A, Stuart.D, Newman.J, King.A.M.Q. (1996) Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate. J Virology 70:5282-5287. [Impact factor 5.308 Feb 2010]
Stephen Curry, Elizabeth Fry, Wendy Blakemore, Robin Abu Ghazaleh, Terry Jackson, Andrew King, Susan Lea, John Newman, David Rowlands, and David Stuart. (1996). Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure, Vol 4, 135-145. [Impact factor 5.397 Feb 2010]
Susan Lea, Robin Abu-Ghazaleh, Wendy Blakemore, Stephen Curry, Elizabeth Fry, Terry Jackson, Andrew King, Derek Logan, John Newman, and David Stuart. (1995). Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67. Structure, Vol 3, 571-580. [Impact factor 5.397 Feb 2010]
S Lea, J Hernéndez, W Blakemore, E Brocchi, S Curry, E Domingo, E Fry, R Abu- Ghazaleh, A King, J Newman, D Stuart, and MG Mateu. (1994) The structure and antigenicity of a type C foot-and-mouth disease virus. Structure, Vol 2, 123-139. [Impact factor 5.397 Feb 2010]
Derek Logan, Robin Abu-Ghazaleh, Wendy Blakemore, Stephen Curry, Terry Jackson, Andrew King, Susan Lea, Richard Lewis, John Newman, Nigel Parry, David Rowlands, David Stuart & Elizabeth Fry. (1993) Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362, 566 – 568. [Impact factor 31.434 Feb 2010]
Curry S, Abu-Ghazaleh R, Blakemore W, Fry E, Jackson T, King A, Lea S, Logan D, Newman J, Stuart D. (1992) Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus. J Mol Biol;228(4):1263-1268. [Impact factor 4.146 Feb 2010]